The Role of Insulin-Like Growth Factor Binding Protein-5 in Bone
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چکیده
منابع مشابه
Insulin-like growth factor I and insulin-like growth factor binding protein 5 in Crohn's disease.
Insulin-like growth factor (IGF)-I and its binding protein IGF binding protein 5 (IGFBP-5) were highly expressed in inflamed and fibrotic intestine in experimental Crohn's disease. IGF-I induced proliferation and increased collagen synthesis by smooth muscle cells and fibroblasts/myofibroblasts in vitro. Here we studied IGF-I and IGFBP-5 in Crohn's disease tissue. Tissue was collected from pati...
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متن کاملInsulin-like growth factor-binding protein-5 (IGFBP-5) stimulates phosphorylation of the IGFBP-5 receptor.
The finding that insulin-like growth factor (IGF)-binding protein-5 (IGFBP-5) binding to mouse osteoblasts was capable of being downregulated by IGFBP-5 suggested that the 420-kDa membrane protein, which interacted with IGFBP-5, may be a signaling receptor (Andress, D. L. J. Biol. Chem. 270: 28289-28296, 1995). In the current study, a carboxy-terminal IGFBP-5 peptide, IGFBP-5-(201-218), which w...
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ژورنال
عنوان ژورنال: Clinical Pediatric Endocrinology
سال: 1997
ISSN: 0918-5739,1347-7358
DOI: 10.1297/cpe.6.supple10_157